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. 2019 Jul 19;8(7):746. doi: 10.3390/cells8070746

Figure 5.

Figure 5

The effect of roscovitine on p38 MAPK phosphorylation in microglia and monocyte following SE. p38 MAPK phosphorylation is increased in resident IB4 microglia following SE, which is abrogated by roscovitine. CD68 amoeboid cells also show the up-regulated p38 MAPK phosphorylation, while roscovitine does not affect it. (A,B) Representative images for p38 MAPK phosphorylation in IB4 microglia and CD68 cells, respectively. (C) Quantification of the effect of roscovitine on p38 MAPK phosphorylation in IB4 microglia and CD68 cells following SE. Error bars indicate SEM (* p < 0.05 vs. vehicle-treated animals; n = 7, respectively).