Table 5.
Multivariate analysis.
| Variables | PFS | OS | ||
|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
| ECOG performance status | ||||
| 1 vs. 0 | 1.902 (1.235–2.929) | 0.004 | 3.074 (1.843–5.125) | <0.0001 |
| Presence of liver metastases | - | - | ||
| no vs. yes | 0.428 (0.244–0.750) | 0.003 | ||
| ETS | ||||
| <20% vs. ≥20% | 1.890 (1.054–3.389) | 0.033 | 2.349 (1.126–4.897) | 0.023 |
| DoR | ||||
| continuous variable | 1.035 (1.022–1.049) | <0.0001 | 1.038 (1.022–1.055) | <0.0001 |
Abbreviations: ECOG, Eastern Cooperative Oncology Group; HR, hazard ratio (95% CI, 95% confidence interval); OS, overall survival; p, p-value; PFS, progression-free survival; ETS, early tumor shrinkage; DoR, depth of response.