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. 2019 Jun 28;8(7):650. doi: 10.3390/cells8070650

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Hypothetical fate of Ddx4⁺ OSCs in post-menopausal women. Under the influence of different hormonal and micro environmental factors related to age or concurrent diseases, Ddx4⁺ OSCs might differentiate into mesenchymal stem cells and/or oocyte-like cells. In postmenopausal women, their mesenchymal differentiation could theoretically support ovarian fibrosis or stromal contribution to cancer development, whereas their oocyte-like induced differentiation could be utilized to restore ovarian hormonal failure or fertility.