Figure 2.

The secretome and genomic profile for 46 AML patients. Primary AML cells derived from a consecutive subset of 46 patients were cultured in vitro for 48 h and the supernatant levels of 34 soluble mediators were then determined. We performed an unsupervised hierarchical cluster analysis (Euclidean measure, and complete distance) based on these results and were then able to identify two distinct patient clusters corresponding to patients with generally high or intermediate/low supernatant level.