. 2019 Jul 17;10(7):545. doi: 10.3390/genes10070545

Table 1.

Human transporters involved in manganese homeostasis that possess a yeast ortholog.

Human Transporter	Yeast Mn²⁺-Transporting Ortholog	Function in Human Cells
DMT1 [33]	Smf1p and Smf2p	Plasma membrane metal importer
DMT1 [33]	Smf1p and Smf2p	Involved in dietary manganese intake
NRAMP1 [20,34]	Smf1p and Smf2p	Plasma membrane metal importer
NRAMP1 [20,34]	Smf1p and Smf2p	Mostly expressed in the phagosome of macrophages where it limits the bioavailability of metals to invading microbes
SPCA1 and SPCA2 [35,36]	Pmr1p	Golgi-localized Ca²⁺ and Mn²⁺ P-type ATPases
SPCA1 and SPCA2 [35,36]	Pmr1p	Involved in manganese detoxification and Golgi Mn²⁺ supply
TMEM165 [27,37]	Gdt1p	Golgi-localized Ca²⁺ and Mn²⁺ secondary transporter
TMEM165 [27,37]	Gdt1p	Putatively involved in manganese detoxification and Golgi Mn²⁺ supply
ATP13A2 [38]	Ypk9p	Putative lysosomal Mn²⁺ transporter
ATP13A2 [38]	Ypk9p	Involved in manganese sequestration in the lysosome
ATP13A1 [29]	Cod1p	Mn²⁺ P-type ATPase at the endoplasmic reticulum
ATP13A1 [29]	Cod1p	Supplies the secretory pathway with manganese