Figure 4.

Transcriptome analysis revealed mitochondrial and age-related pathways were affected by the mt-Nd2 mutation. (A) Differentially expressed genes between B6-mt^ALR and B6-mt^BPL mice. The volcano plot shows the effect size versus the -log10 p-value of differentially regulated genes. Genes with the expression levels p < 0.01 were plotted in red. n = 4/strain, female. BPL: B6-mt^BPL; ALR: B6-mt^ALR. (B) Hallmark pathway analysis show the pathways upregulated in B6-mt^ALR mice (left) and upregulated in B6-mt^BPL mice (right).