Table 3.
Analysis of hypoxia-inducible factor 1-alpha (HIF1a) and von Hippel–Lindau (VHL) mRNA expression in relation to chromosome status and BAP1 (based on the n = 54 lesions with data on HIF1a/VHL and chromosome status from the Leiden data).
| Total | HIF1a | VHL | |||
|---|---|---|---|---|---|
| CATEGORICAL | Cases (%) | Median | p-Value | Median | p-Value |
| All patients | |||||
| Chromosome 3 | |||||
| D3 | 20 (37) | 7.02 | 0.001 * | 8.23 | <0.001 * |
| M3 | 34 (63) | 7.24 | 7.69 | ||
| Chromosome 8q | |||||
| Normal | 13 (24) | 7.01 | 0.003 * | 8.22 | 0.001 * |
| Gain | 41 (76) | 7.24 | 7.74 | ||
| BAP1 IHC | |||||
| Negative | 30 (56) | 7.28 | <0.001 * | 7.71 | 0.003 * |
| Positive | 24 (54) | 7.02 | 8.17 | ||
| Sub-group analysis | |||||
| Within D3 Lesions | |||||
| D3/BAP1− | 3 | 7.30 | 0.028 * | 8.23 | 0.921 |
| D3/BAP1+ | 17 | 7.01 | 8.23 | ||
| Within M3 Lesions | |||||
| M3/BAP1− | 27 | 7.25 | 0.015 * | 7.70 | 0.647 |
| M3/BAP1+ | 7 | 7.10 | 7.56 | ||
| Within D3/BAP1+ Lesions | |||||
| D3/BAP1+/n8q | 9 | 6.98 | 0.200 | 8.22 | 1.000 |
| D3/BAP1+/8qgain | 8 | 7.07 | 8.32 |
The p-values were calculated with the Mann–Whitney U test; * indicates significant p-values. Abbreviations: BAP1+, BAP1-positive; BAP1−, BAP1-negative; n8q, normal chromosome 8q; 8qgain, gain of chromosome 8q; D3, disomy 3; M3, monosomy 3; IHC, immunohistochemistry.