Table 4.
Univariate and multivariate regression analysis on hypoxia-inducible factor 1-alpha (HIF1a) and von Hippel–Lindau (VHL) mRNA expression (based on the n = 54 lesions with data on HIF1a/VHL and chromosome status from the Leiden data).
| HIF1a | VHL | |||
|---|---|---|---|---|
| Variables | B (95% CI) | p-Value | B (95% CI) | p-Value |
| Univariate Regression | ||||
| Chr. 3 (M3 vs. D3) | 0.17 (0.03; 0.32) | 0.019 * | −0.51 (−0.65; −0.37) | <0.001 * |
| BAP1 (BAP1− vs. BAP1+) | −0.26 (−0.39; −0.14) | <0.001 * | 0.31 (0.13; 0.48) | 0.001 * |
| LBD (per mm increase) | −0.01 (−0.03; 0.01) | 0.208 | −0.03 (−0.05; −0.002) | 0.034 * |
| Multivariate Regression | ||||
| Model 1 | ||||
| Chr. 3 | 0.01 (−0.16; 0.17) | 0.952 | −0.51 (−0.70; −0.33) | <0.001 * |
| BAP1 | −0.26 (−0.43; −0.10) | 0.002 * | −0.01 (−0.18; 0.17) | 0.957 |
| Model 2 | ||||
| LBD | −0.02 (−0.03; 0.002) | 0.086 | −0.03 (−0.05; −0.002) | 0.034 * |
| BAP1 | −0.27 (−0.40; −0.15) | <0.001 * | 0.30 (0.13; 0.47) | 0.001 * |
| Model 3 | ||||
| LBD | −0.02 (−0.04; 0.00) | 0.055 | −0.01 (−0.03; 0.006) | 0.173 |
| Chr. 3 | 0.20 (0.06; 0.35) | 0.006 * | −0.49 (−0.63; −0.34) | <0.001 * |
| Univariate Regression | ||||
| Within D3 (n = 20) | ||||
| LBD | −0.05 (−0.10; 0.004) | 0.067 | −0.04 (−0.08; −0.004) | 0.033 * |
| Within M3 (n = 34) | ||||
| LBD | −0.01 (−0.03; 0.008) | 0.230 | −0.006 (−0.03; 0.02) | 0.605 |
* indicates significant p-values. Abbreviations: CI, confidence interval; Chr. 3, chromosome 3; LBD, largest basal diameter; D3, disomy 3; M3, monosomy 3.