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. 2019 Jul 16;20(14):3493. doi: 10.3390/ijms20143493

Figure 1.

Figure 1

Glucocorticoid receptor is effectively knocked down at the protein and mRNA level. The glucocorticoid receptor (GR) siRNA repressed GR expression in the neonatal rat brain. The neonatal rats received either GR siRNA (100 pmol) or negative control (100 pmol) via intracerebroventricular (ICV) injection seven days after birth (P7). The brain samples were collected 48 h after ICV treatment and glucocorticoid receptor (GR) protein abundance was evaluated via Western blotting (A) and mRNA abundance was evaluated (B) via real-time RT-qPCR relative to GADPH, respectively. Data are means ± SEM. n = 5. ** p < 0.01 *** p < 0.001, GR siRNA vs. negative control.