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. 2019 Jul 16;20(14):3493. doi: 10.3390/ijms20143493

Figure 3.

Figure 3

Design/timeline of short- and long-term behavioral tests after hypoxic-ischemic injury. The neonatal male rats received GR siRNA (100 pmol) or negative control (100 pmol) by ICV injection on postnatal day 7 (P7). Animals were then divided into two groups, Sham and HIE. Hypoxic-ischemic injury was performed on postnatal day 9 with carotid ligation and subsequent 8% O2 exposure for 60 min. Animals in sham group had carotid arteries exposed without subsequent hypoxic-ischemic injury induction. HI-injury was performed on postnatal day 9 (P9) for 60 min in 8% FiO2. Pups were returned to dams. Neurobehavioral tests began two days after injury and extended to 9 weeks after initial injury.