Figure 7.

Repression of GR and long-term neurobehavioral deficits in the neonatal male rat with mild HI injury. The neonatal male rats received GR siRNA (100 pmol) or negative control (100 pmol) by ICV injection 48 h before HI-injury (8% FiO₂; 60 min). Groups were sham (negative Control; (n = 12) versus negative control with HI injury (n = 13) versus GR siRNA (n = 11) with HI injury. (A–D) Morris water maze cued training to spatial learning day 3 testing for the distance moved before arrival to the platform. (E–H) Cued training to spatial learning day 3 for the latency to platform in seconds. (I,J) Probe trials performed before Spatial 2 and 3. (K,L) Open-field test. * p < 0.05, *** p < 0.01, **** p < 0.001, two-way ANOVA group (sham vs. negative control vs. GR siRNA) effect. # p < 0.05, ## p < 0.01, ### p < 0.001 sham vs. GR siRNA. † p < 0.05, negative control vs. GR siRNA.