Figure 8.

Repression of the GR increases cytokine profile 6 h after mild HI injury. The neonatal male rats received GR siRNA (100 pmol) or negative control (100 pmol) by ICV injection 48 h before HI-injury (8% FiO₂; 60 min). Groups were sham with negative control, sham with GR siRNA, negative control with HI injury, and GR siRNA with HI injury. Whole brain RNA was isolated at six, 12, and 24 h after HI injury and cytokines TNF-α (A–C), IL-10 (D–F), IL-6 (G–I), and IL-1β (J–L). * p < 0.05, ** p < 0.01, **** p < 0.0001.