Table 1.

Summary of the diagnostic and prognostic values of STIM/Orai in human cancers.

SOCE Molecule	Cancer Type	Expression in Tumor		Diagnostic/Prognostic Significance	Reference
		mRNA	Protein
STIM1	Cervical	N/A 1	↑	Tumor size: ↑ Lymph-node metastasis: ↑ Survival: ↓	[30]
STIM1	Colorectal	↑	↑	Poor differentiation Tumor invasion: ↑ Lymph-node metastasis: ↑	[32,33]
STIM1/ STIM2	Breast	↑	N/A	Survival: ↓	[45]
STIM2	Colorectal	↑	N/A	Cancer cell invasion: ↓	[43]
Orai1	Esophageal	N/A	↑	Overall survival: ↓ Recurrence-free survival: ↓	[40]
Orai1	Multiple myeloma	↑	↑	Progression-free survival: ↓	[37]
Orai3	Lung	N/A	↑	Higher tumor grades Visceral pleural invasion: ↑ Overall survival: ↓ Metastasis-free survival: ↓	[47,48]

¹ N/A, not applicable.