Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
GPI anchor remodeling in mammalian cells at the ER. Newly synthesized GPI-APs undergo two remodeling reactions, inositol-deacylation by PGAP1 and removal of the EtNP side chain from Man2 by PGAP5 in the ER. Next, the p24 complex recognizes the remodeled GPI-APs and connect them with the COPII coat for ER export in COPII vesicles. In the Golgi, GPI-APs undergo fatty acid remodeling by PGAP3 and PGAP2, generating mature GPI-APs (not shown).
