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. 2019 Jul 11;11(7):972. doi: 10.3390/cancers11070972

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The decrease in JNK activation is related to RH1 resistance. (A). Western blot analysis showing the level of pJNK (Thr183/Tyr185) in MDA-P and MDA-R cells. α-tubulin is shown as loading control. (B). Densitometric analysis of pJNK and JNK western blot. Bars are ± SD, significant difference is marked by asterisks: ** p < 0.05, t-test, n = 4. (C). Viability test after JNK inhibition. MDA-P and MDA-R cells were pre-treated with JNK inhibitor SP600125 for 1 h and then treated with increasing concentrations of RH1 for 2 h. Cell survival after 96 h was estimated by MTT assay. Bars are ± SD, significant differences are marked by asterisks: * p < 0.1, ** p < 0.05, *** p < 0.01, ANOVA, n = 3.