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. 2019 Jul 20;20(14):3554. doi: 10.3390/ijms20143554

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Overview of sphingolipid biosynthesis-associated trafficking (simplified). Solid arrows: enzyme mediated reaction; dashed arrows: transport event; SPT = serine palmitoyl transferase; GCS = Glucosylceramide synthase; SMS1 = sphingomyelin synthase 1; CerK = ceramide kinase; SK1 = Sphingosine kinase 1; MCS = membrane contact site; TGN = trans Golgi network; ER = endoplasmic reticulum. Grey channels: not clearly defined transporters that likely include members of the ABC family of transporters like MDR1/p-glycoprotein.