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. 2019 Jul 9;11(7):959. doi: 10.3390/cancers11070959

Figure 2.

Figure 2

Methylation level of 48 CpGs in the promoter and first exon of RASSF1A in five normal tissue types. Results of bisulfite DNA sequencing on liver, esophagus, pancreas, colon, and stomach tissues samples taken from a 34-year-old healthy subject. The grey/blue vertical bars represent 48 CpGs overlapped to the promoter of RASSF1A and partially to first exon and CpG island A. For each CpG, the blue line is the number of reads for the 5mC and grey is the total number of reads (number of reads per kilobase per million mapped reads, RPKM) obtained by bisulfite DNA sequencing. The ratio between the two numbers represents the methylation level of a CpG. The grey bar at the bottom of the figure identifies the 3′ end of the CpG island A. The data were retrieved by the WashUp EpiGenome Browser at www.epigenomegateway.wustl.edu, provided by the Roadmap EpiGenome Project [69].