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. 2019 Jul 1;11(7):924. doi: 10.3390/cancers11070924

Figure 3.

Figure 3

A four-marker signature built of G-Protein coupled estrogen receptor (GPER), MUC-1 and Gal-3/8 is associated with ECG in associated lymph nodes: Four out of 26 markers * turned out to be predictive for presence of ECG in associated retroperitoneal lymph node metastasis (A–D) as determined by receiver operating characteristic (ROC) analysis using SPSS v22 (A–E). Diagonal segments are produced by ties. Likelihood of the state event (ECG) was associated with decrease in test variable in case of GPER, Gal-3nuc, and Gal-8nuc (A,C,D). Regarding VU4H5, likelihood of the state event (ECG) was associated with increase in test variable (VU4H5, B). Primary tumors expressing GPER, Gal-3nuc, and Gal-8nuc at low and MUC-1 (as detected by VU4H5) at high levels were more likely to present extracapsular metastatic spread in respective, case-matched lymph node specimens (A–D). A signature combining GPER, VU4H5, Gal-3, and Gal-8 was calculated and tested for its diagnostic strength to discriminate ECG from ICG cases (E). * Data on p53 mutational status (i.e., 27th biomarker) in relation to ICG/ECG are presented in the text. There was no difference regarding the prevalence of ECG and ICG with respect to p53 mutation of the primary tumor.