Table 4.
Amino Acid Variability was estimated for each NS5A amino acid position for each patient.
| Patient ID | HCV Infection |
Number Cluster |
Sn a | Overall HCV Infection | Sn Median (IQR) | p Value b |
|---|---|---|---|---|---|---|
| Patients with β-thalassemia | ||||||
| 1 | Acute | 1 | 0.23 | |||
| 4 | Acute | 2 | 0.35 | |||
| 5 | Acute | 2 | 0.36 | Acute | 0.34 (0.27–0.36) | |
| 10 | Acute | 4 | 0.31 | |||
| 2 | Chronic | 1 | 0.65 | 0.01 c | ||
| 3 | Chronic | 2 | 0.93 | |||
| 6 | Chronic | 3 | 0.66 | |||
| 7 | Chronic | 3 | 0.80 | Chronic | 0.66 (0.60–0.81) | |
| 9 | Chronic | 3 | 0.59 | |||
| 8 | Chronic | 4 | 0.38 | |||
| Patients with onco-hematologic disease | ||||||
| 11 | Acute | 5 | 0.59 | |||
| 12 | Acute | 5 | 0.54 | |||
| 13 | Acute | 5 | 0.41 | Acute | 0.55 (0.54–0.60) | 0.02 d |
| 14 | Acute | Out of cluster | 0.68 | |||
| 15 | Acute | 5 | 0.53 | |||
a Sn, Shannon Entropy weighted for the intra-patient prevalence of viral species, b p value was calculated using the Mann–Whitney test. c Acute vs chronic; d acute vs acute.