. 2019 Jul 22;20(14):3581. doi: 10.3390/ijms20143581

Table 1.

The effects of brain natriuretic peptide (BNP) infusion on renal function, the renin angiotensin II aldosterone system and hemodynamics in normal subjects and patients with heart failure and hypertension.

Study/Reference	Dosage of BNP pmol/kg/min	GFR	RPF	Urine Volume	Urine Na	Urine cGMP	Urine Aldo	Plasma cGMP	PRA	AngII	Plasma Aldo	MAP	HR	CO	SVR	PCWP
Normal Subjects
McGregor. J. Clin. Endocrinol. Metab. 1990 [36]	2				↑↔ *	↑			↓		↓	↔	↔
Yoshimura. Circulation. 1991 [37]	30			↑	↑			↑	↔		↓	↓	↑	↑	↓	↓
Holmes. J. Clin. Endocrinol. Metab. 1993 [9]	2			↔	↑	↑		↑	↓↔ *		↓	↔	↑
Cheung. Clin. Sci. 1994 [38]	0.4	↔		↔	↑							↔	↔
Florkowski. Am. J. Physiol. 1994 [39]	2(+ANP(2)) **	↔			↑	↑		↑	↔	↔	↔	↓	↔
La Villa. J. Clin. Endocrinol. Metab. 1994 [40]	4	↑	↑	↑	↑	↑			↔		↔	↔	↔	↔	↔
La Villa. Hypertension. 1995 [41]	0.25 and 0.5	↔	↔	↔	↑	↑	↓		↓			↔	↔
Lazzeri. Cardiology. 1995 [42]	4, 8, 10, 12							↑	↔			↔	↑	↔	↔
Hunt. J Clin. Endocrinol. Metab. 1996 [43]	2	↔		↑	↑			↑	↓↔ *	↓	↓	↔	↑
Yasue. J Card. Fail. 1996 [44]	30	↑		↑	↑			↑				↓	↑		↓	↓
Jensen. Am. J. Phy.1998 [35]	1, 2 and 4	↑	↓	↑	↑	↑		↑	↓	↔	↔	↔	↔
Jensen. Clin. Sci. 1999 [5]	2	↑	↓ ***	↔	↑	↑		↑	↓	↔	↔	↑	↔
van der Zander. Am. J. Physiol. 2003 [45]	4	↑	↔	↑	↑			↑				↔	↔	↓↔ *	↔
Summarized		↑	↔	↑	↑	↑		↑	↓↔	↔	↓	↔	↔	↔	↔	↓
Patients with Heart Failure
Yoshimura. Circulation. 1991 [37]	30			↑	↑			↑	↔		↓	↓	↑	↑	↓	↓
Marcus. Circulation. 1996 [46]	1 to 30	↔		↑	↑			↑				↓	↓	↑	↓	↓
Yasue. J. Card. Fail. 1996 [44]	30	↔		↑	↑			↑				↔	↔		↓	↓
Lainchbury. HTN 1997 [47]	3.3	↔		↔				↑	↔		↔	↓	↔	↔	↓	↓
Abraham. J. Cardiac. fail. 1998 [48]	7.5, 15	↔	↔	↔	↔			↑	↔		↓	↓	↔	↑	↓	↓
Jensen. Clin. Sci. 1999 [5]	2	↔	↔	↔	↑	↑		↑	↓	↔	↔	↑	↔
Wang. Am. J. Trans. Res. 2016 [49]	A bolus followed by 2 to 6 for 72 h	↓										↓
Summarized		↔	↔	↑	↑	↑		↑	↔	↔	↓	↓	↔	↑	↓	↓
Patients with Hypertension
Richards. J. Hypertension. 1993 [50]	2	↔		↑	↑	↔		↑	↔ ^#		↓	↔	↔
Lazzeri. Am. J. Hypertension. 1995 [51]	4	↑		↑	↑	↑			↔			↔	↔	↔	↔
Pidgeon. Hypertension. 1996 [52]	2	↑		↑	↔			↑	↓		↓	↓	↑
Summarized		↑		↑	↑			↑	↔		↓	↔	↔

ANP, atrial natriuretic peptide; cGMP, cyclic guanosine monophosphate; CO, cardiac output; GFR, glomerular filtration rate; HR, heart rate; MAP, mean arterial pressure; PCWP, pulmonary capillary wedge pressure; PRA, plasma renin activity; RPF, renal plasma flow; SVR, systemic vascular resistance. * marginal significance. ** BNP(2)+ANP(2) vs ANP(2) alone. *** after the infusion. ^# Plasma renin concentration.