Table 1.
Baseline characteristics of the study population according to the presence of familial hypercholesterolemia phenotype (FH-P) and previous arteriosclerotic cardiovascular disease (ASCVD).
| Normal LDL-C < 115 mg/dL |
FH-P | Normal LDL-C < 115 mg/dL |
FH-P | |||
|---|---|---|---|---|---|---|
| Variable | Without ASCVD | Without ASCVD | P Value | With ASCVD | With ASCVD | P Value |
| N | 472,591 | 10,621 | 41,585 | 2202 | ||
| Age, mean (SD) | 48.2 (19.3) | 60.5 (13.6) | <0.01 | 73.2 (12.1) | 67.7 (10.7) | <0.01 |
| Male, sex, % | 40.9% | 40.9% | 0.98 | 64.5% | 63.3% | 0.34 |
| Diabetes, mellitus, % | 14.2% | 21.7% | <0.01 | 44% | 36.7% | <0.01 |
| Hypertension, % | 33.6% | 60.7% | <0.01 | 91.8% | 93.3% | 0.03 |
| Current, smoker, % | 30.3% | 32.3 | <0.01 | 43.3% | 49.1 | <0.01 |
| BMI, mean (SD) | 27.5 (5.6) | 28.9 (4.7) | <0.01 | 28.8 (4.9) | 29.2 (4.5) | <0.01 |
| Receiving lipid therapy, % | 4.1% | 87.1% | <0.01 | 36.3% | 97.4% | <0.01 |
| Personal history of CAD, % | - | - | - | 36.3% | 46.9% | <0.01 |
| Personal history of PAD, % | - | - | - | 16.7% | 15.6% | 0.27 |
| Personal history of Stroke, % | - | - | - | 30.4% | 22.8% | <0.01 |
| TC, mg/dL, mean (SD) | 169.9 (26.1) | 257.9 (59.5) | <0.01 | 160.8 (29.5) | 223.9 (5) | <0.01 |
| LDL-C, mg/dL, mean (SD) | 91.8 (17.9) | 177.6 (55.5) | <0.01 | 85.4 (20.4) | 147.1 (46.0) | <0.01 |
| Untreated LDL-C, mg/dL, mean (SD) | 92.3 (16.6) | 285.2 (34.7) | <0.01 | 93.08 (16.7) | 287.5 (3) | <0.01 |
| HDL-C, mg/dL, mean (SD) | 56.1 (16.3) | 56.3 (13.8) | 0.23 | 49.3 (15.2) | 51.6 (13.0) | <0.01 |
| Non-HDL-C, mg/dL, mean (SD) | 113.7 (24.2) | 201.7 (59.3) | <0.01 | 111.4 (26.7) | 172.3 (51.3) | <0.01 |
| TG, mg/dL, mean (SD) | 111.2 (74.1) | 149.1 (88) | <0.01 | 127.3 (81.8) | 150.6 (83.1) | <0.01 |
| Creatinine, mean (SD) | 0.85 (0.3) | 0.89 (0.2) | <0.01 | 1.08 (0.6) | 1.03 (0.4) | <0.01 |
| HBA1c, mean (SD) | 5.7 (1.5) | 6.02 (1.5) | <0.01 | 6.2 (1.4) | 6.2 (1.6) | 0.55 |
LDL-C: Low-density lipoprotein cholesterol; TC: Total Cholesterol; HDL-C: High-density lipoprotein cholesterol; TG: triglycerides; HbA1C: Glycosylated haemoglobin; BMI: Body Mass Index; CAD: Coronary Artery Disease; PAD: Peripheral Arterial Disease.