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. 2019 Jul 4;11(7):942. doi: 10.3390/cancers11070942

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) Median effect plot showing the inhibition of cell proliferation of PANC-1 and MIAPaCa-2 cells after 48 h treatment with XAV-939 (0.001–100 µM) as log (fraction affected/fraction unaffected) vs. log(dose). (b) Effect of XAV-939 on PDAC cells migration was assessed in wound healing assay: XAV-939 treatment restrains PDAC migration function in vitro. WNT-β-catenin inhibition reduced the capacity of tumor cell migration. Differences in wound closure were assessed by ImageJ Lab 1.51 Software. Graph bars represent the percentage of surface area in three independent experiments. Values are expressed as mean ± SD of three independent experiments; **** p-value < 0.0001, by t-test. (c) The invasion of PANC-1 and MIAPaCa-2 cells was performed with or without 10 µM XAV-939 by Boyden chambers assay showing the high capability of the drug in reducing PANC-1 cell invasion.

(a) Median effect plot showing the inhibition of cell proliferation of PANC-1 and MIAPaCa-2 cells after 48 h treatment with XAV-939 (0.001–100 µM) as log (fraction affected/fraction unaffected) vs. log(dose). (b) Effect of XAV-939 on PDAC cells migration was assessed in wound healing assay: XAV-939 treatment restrains PDAC migration function in vitro. WNT-β-catenin inhibition reduced the capacity of tumor cell migration. Differences in wound closure were assessed by ImageJ Lab 1.51 Software. Graph bars represent the percentage of surface area in three independent experiments. Values are expressed as mean ± SD of three independent experiments; **** p-value < 0.0001, by t-test. (c) The invasion of PANC-1 and MIAPaCa-2 cells was performed with or without 10 µM XAV-939 by Boyden chambers assay showing the high capability of the drug in reducing PANC-1 cell invasion.