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. 2019 Jul 19;8(7):745. doi: 10.3390/cells8070745

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Influence of melatonin, EGCG and the combination on cell viability, p21, γ-H2AX and histone H3 in HepG2 cells. (A) Influence of 1.5 mM melatonin on p21 and p53. (B) Influence of 3 mM melatonin, 400 μM EGCG and the combination on p21. (C) Influence of 3 mM melatonin, 400 μM EGCG and the combination on cell viability measured by MTT assay. (D) Influence of 3 mM melatonin, 400 μM EGCG and the combination on γ-H2AX. (E) Influence of 3 mM melatonin, 400 μM EGCG and the combination on histone H3 (H3). Data are presented as mean ± SEM (n = 6 in C or 3 in A, B, D, E). Compared to the control, * p < 0.05, ** p < 0.01 and *** p < 0.001. Compared to 400 μM EGCG, # p < 0.05.