Table 1.

Common FGFR genomic aberration in solid tumors. FGF signaling deregulation is involved in the development of many different human cancers. Four FGFR genomic alterations are represented in this table: gene amplification, point mutations, chromosomal translocations, and FGFR splicing isoforms. Each FGFR alteration is linked with the most significant cancers that contain those alterations. The role of the majority of the discovered point mutations in FGFR is unknown in cancer. Adapted from [10,18].

Gene	Gene Amplifications	Point Mutations	Chromosomal Translocations	Splice Variants
FGFR1	Breast, ovarian, bladder, and lung cancer	Majority of cancers. Example: Melanoma	Stem cell leukemia/lymphoma (SCLL), GBM	IIIc: small cell lung carcinoma Iβ: breast cancer and GBM
FGFR2	Breast, gastric, lung cancer	Majority of cancers. Example: Endometrial carcinoma		IIIb: breast, endometrial, cervical, lung, pancreatic and colorectal cancer IIIc: prostate cancers
FGFR3	Bladder cancer	Majority of cancers. Example: bladder cancer	GBM, T-cell lymphoma and bladder	IIIc: bladder cancer
FGFR4	Colorectal cancer	Majority of cancers. Example: metastatic breast cancer and rhabdomyosarcoma