Figure 6.
Flavopereirine significantly inhibited in vivo HCT116-xenograft growth. HCT116-bearing mice were treated either with PBS (n = 8) or flavopereirine (10 mg kg−1 d−1) (n = 8). (A) Representative images of excised tumors from each group. (B) Tumor volumes were measured to reflect tumor growth. ** p < 0.01, *** p < 0.001 compared with PBS. (C) Tumor weights were compared on the last day of treatment. *** p < 0.001 compared with PBS. (D,E) P53 and P21 expression levels in HCT116 tumors were evaluated by immunohistochemical staining. Scale bar: 100 µm. (F) Apoptosis in HCT116 tumors was measured by TUNEL staining. *** p < 0.001 compared with PBS. Scale bar: 100 µm.