Table 1.

Numerical values of the major endpoints reflecting clinical, cellular, and molecular radiosensitivity ¹.

Radiosensitivity of the Patients	CTCAE/RTOG Grade	SF2 (%)	γH2AX Foci at 10 min Post-Irradiation	pATM Foci at 10 min Post-Irradiation	γH2AX foci at 24 h Post-Irradiation
Group I	0	50–70	70–80	30–40	0–2
Group II	0–4	10–50	10–70	10–30	2–8
Group III	5	1–10	IIIa2: 0–5 IIIb2: 70–80	IIIa: 0 IIIb: 30–40	IIIa: 0–5 IIIb: 30–40

¹ Experimental values were taken from [35]. The subgroup IIIa gathers syndromes with gross defects in the DSB recognition step like those caused by ATM mutations; the subgroup IIIb gathers syndromes with gross defects in the DSB joining step like those caused by LIG4 mutations [35].