Figure 10.

(A) Overview of target lesion (TL) assessment (identical target lesion included by all four readers on 50 PSMA-positron emission tomography (PET)/computed tomography (CT) scans with ¹⁸F-DCFPyL). The following organ compartments were defined: lymph nodes (LN), skeleton, prostate/local recurrence, soft tissue (other than LN), liver, thyroid, and lung. A PSMA-RADS Score had to be assigned to every target lesion by every blinded reader (ER, experienced reader, IR, inexperienced reader). Often, characterizing a lesion as PSMA-RADS-1B involves previous conventional imaging or histologic diagnosis; as such, PSMA-RADS-1A and -1B were subsumed under PSMA-RADS-1 in the present blinded interobserver agreement study. (B) Overview of overall PSMA RADS scoring for four blinded readers (ER, IR, assessment of 50 ¹⁸F-DCFPyL PET/CT scans). For the TL and overall scan impression, a high interreader agreement rate, even among IRs, was noted. Modified from Werner et al. [70], © by the Society of Nuclear Medicine and Molecular Imaging, Inc.