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. 2019 Jul 8;11(7):957. doi: 10.3390/cancers11070957

Figure 1.

Figure 1

Structures of the chemically labile antibody-drug conjugates (ADCs) with acid-cleavable linkers, and the drug release mechanism of ADCs with monomethyl auristatin E (MMAE) as the payload. (A) The doxorubicin-based ADC with the pH-sensitive hydrazone linker; (B) the calicheamicin-based ADC with the pH-sensitive hydrazone linker; (C) the SN-38-based ADC with the pH-sensitive carbonate linker; (D) the designed MMAE-based ADC with the pH-sensitive silyl ether linker, and its drug release mechanism.