Figure 8.

Xenograft studies of the ADC (mil40-6). Nude mice were implanted subcutaneously with NCI-N87 cells. When the tumors reached ~ 120 mm³, the animals were given vehicle, mil40, and ADC on: Days 0, 7, 14, and 21. Results are shown as mean ± SD, n = 6/group. (A) The tumor volume of the test animals during the treatment and observation period; (B) changes in body weight of the mice during the observation period. To compare the difference in activity between antibody and ADC, unpaired two-tailed t tests for multiple comparisons were used, and statistical analyses were performed using Prism5 for Windows.