Table 1.
Cytotoxicity of ADC, antibody and cytotoxin in cancer cell lines in vitro.
| Cell Lines | HER2 Status | ADC | mil40 | MMAE | |||
|---|---|---|---|---|---|---|---|
| IC50 (nM) | Max. Inhibition | IC50 (nM) | Max. Inhibition | IC50 (nM) | Max. Inhibition | ||
| BT-474 | HER2+++ | 0.170 | 50.50% | 0.323 | 61.25% | 0.400 | 40.65% |
| NCI-N87 | HER2+++ | 0.028 | 93.54% | 1.157 | 45.80% | 0.369 | 68.22% |
| MDA-MB-453 | HER2++ | 0.101 | 87.30% | 0.315 | 34.80% | 0.295 | 83.79% |
| MCF-7 | HER2− | 7.742 | 47.8% | >1000 | - | 0.688 | 77.64% |
| MDA-MB-231 | HER2− | >1000 | - | >1000 | - | 1.156 | 53.4% |
Note: the concentration of the ADC was calculated as the concentration of the antibody.