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Diprovocim (TLR1/TLR2 agonist) acts in combination with anti-PD-L1 to cause tumour cell lysis, leading to a 100% survival rate in mice. Anti-PD-L1 decreases the inhibition of immune cells to allow an unrestrained response against tumours. Diprovocim increases antigen presentation and cytokine release, increasing immune cell proliferation [63].
