Table 2.

Overview of the 38 differentially expressed mRNA levels of proteins belonging to the GO-term “TLR signaling” and their function in the TLR pathway. The three proteins in bold were found to be overexpressed in the patient subset with reduced response towards TLR targeting.

Function	Proteins
Chaperone, translocation	CNPY3/PRAT4A, UNC93B1
TLR cleavage	CTSB, CTSS
Agonists	S100A8, S100A9
Receptors	TLR1, TLR4, TLR5, TLR6, TLR7, TLR8
Co-receptors	CD14, CD36, CD86, LY96/MD2
Adaptors, co-factors	CTSL1, MYD88, PIK3AP1/BCAP, TICAM2/TRAM
Downstream targets	CYBA, MAP3K1/MEKK1, PELI1
Positive regulators/feedback pathways	CAV1, FLOT1, LTF
Negative regulators/feedback pathways	ARRB2, CD300A, CD300LF, HAVCR2/TIM-3, IRAK3/IRAK-M, ITGAM/CD11b, ITGB2, LYN, NFKBIA, PIK3AP1/BCAP, RAB7B, TANK, TNFAIP3