Table 3.
Overview over the 75 transcription-associated proteins that were found to be overexpressed in TLR non-responding patient cells. Proteins in bold have been studied or identified as overexpressed in AML.
| Protein Task | Protein Group | Protein Names | Protein Names (Putative Task) |
|---|---|---|---|
| Pre-Transcription | |||
| Chromatin remodeling | |||
| Polycomb | ASXL1, BMI1, CBX2, EZH2, SCMH1 | ||
| SWI/SNF | ARID2, CHD8, SMARCC1, SMARCD1 | CHD9 | |
| WD40-repeats | BRWD1, FBXW9, RBBP4, WDR33 | WDR42A | |
| Chromatin modification | SETD1A, ZMYM3 | ||
| Chromatin binding | MED12, MYST3, MYST4, RCOR3 | C14orf106 | |
| Transcription | |||
| TFs | Activation and/or regulation | DACH1, ELF2, FOXJ3, ILF3, MYST4, MZF1, NFX1, RFX7, SCMH1, TP53INP1, ZBTB20, ZNF395, ZNF521, ZNF548, ZNF880 | CCDCC171, KANSL3, RCOR3, UBN2, ZNF521, ZNF669, ZNF700, ZNF763, ZNF789 |
| Transcription repressors | TRIM33, ZNF219, ZNF431, ZNF521 | ||
| Post-Transcription | |||
| Pre-mRNA splicing | SFRS8, SFRS14, SNRNP200, TCF3, WDR33, YTHDC1 | EXOC7, PSIP1 | |
| mRNA degradation | DCP1A | ||
| Ubiquitination | |||
| E3 ubiquitin ligases | CCNB1IP1, DDB1, FBXO46, FBXW9, HECTD2, HECTD4, HERC1, MAGEL2, MARCH5, RNF19A, RNF144, RNF144A, SIAH1 | ||
| Other tasks with ubiquitination | CUL9, KLHL | COMMD3, WDR42A | |
| De-ubiquitination | OTUD5, USP4 | BABAM1 |