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. 2019 Jul 15;20(14):3480. doi: 10.3390/ijms20143480

Figure 3.

Figure 3

Sequence conservation of miRNA response elements (MREs) and target sites of known and potentially novel miRNAs. Single nucleotide polymorphism (SNP) density distribution along the miRNA binding sites and the flanking regions (up- and down-stream 60 nt, respectively) in (a) competing endogenous RNAs (ceRNAs) of known miRNAs, (b) target genes of known miRNAs by psRobot software and (c) by TAPIR program. SNP density distribution along the miRNA binding sites and the flanking regions in (d) ceRNAs of potentially novel miRNAs and (e) target genes of potentially novel miRNAs by TAPIR program. There were four predicted target genes by using the psRobot program for potentially novel miRNAs, but no SNP site existed at the four target sites and their flanking regions. “MRE and target site” indicate binding regions recognized by mature miRNA sequences on predicted ceRNA and target genes respectively, and are marked in blue. “5′-side” represents binding regions recognized by the 2nd to 7th nucleotides from the 5′ end of miRNA mature sequences (marked in red).