Table 1.
Patient characteristics.
| Controls (n = 15) | COPD (n = 29) | ||
|---|---|---|---|
| Demographics | |||
| Age, years | 65 (6) | 65 (6) | NS |
| Sex, % men | 60 | 55 | NS |
| BMI, kg/m2 | 24.9 (3.3) | 25.5 (3.6) | NS |
| Pulmonary function | |||
| FEV1, % pred | 113 (15) | 58 (16) | p ≤ 0.001 |
| FVC, % pred | 120 (17) | 104 (22) | p = 0.016 |
| FEV1/FVC, % | 74 (5) | 45 (11) | p ≤ 0.001 |
| DLCO, % pred | 95 (19) | 53 (18) | p ≤ 0.001 |
| Muscle Biopsy | |||
| PGC1α gene expression (AU) | 0.019 (0.008) | 0.011 (0.005) | p ≤ 0.001 |
| ETC complex IV protein expression (AU) | 5.11 (3.51) | 2.71 (1.97) | p = 0.024 |
| ETC complex V protein expression (AU) | 0.83 (0.50) | 0.57 (0.33) | p = 0.047 |
Abbreviations: COPD, chronic obstructive pulmonary disease; BMI, body mass index; DLCO, diffusion capacity of the lungs for carbon monoxide; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; ETC, electron transport chain (mitochondrial proteins); NS, not significant; % pred, % predicted. Data are presented as mean (SD). Adapted from [9].