Table 4.
Summary of Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of DEGs (only significant pathways listed).
| Pathway | p-Value | Genes | |
|---|---|---|---|
| 2d vs. 0d | Steroid hormone biosynthesis | 0.00259 | HSD11B2, AKR1C1 |
| 4d vs. 0d | PPAR signaling pathway | 0.00017 | SCD, ANGPTL4, GK |
| Steroid hormone biosynthesis | 0.01279 | HSD11B2, AKR1C1 | |
| Cell cycle | 0.01253 | CDC20, CCNB1, WEE1 | |
| 8d vs. 0d | PPAR signaling pathway | 0.00077 | CD36, ANGPTL4, GK |
| Steroid hormone biosynthesis | 0.02929 | HSD11B2, AKR1C1 | |
| p53 signaling pathway | 0.04143 | CDK1, CCNB1 | |
| PI3K/Akt signaling pathway | 0.03306 | ITGA3, COL6A3, AREG, THBS3, TLR2, HGF, FGF1, ANGPT2, SPP1, MYC | |
| Wnt signaling pathway | 0.03833 | SFRP5, SFRP2, PORCN, MYC, WNT2B | |
| Cellular senescence | 0.02123 | CDK1, CCNB1, CXCL8, CCNB3, MYC | |
| TNF signaling pathway | 0.00215 | CCL2, MAP3K8, CX3CL1, CSF2, FOS |
PPAR: peroxisome proliferator-activated receptor, PI3K: phosphoinositide 3-kinase, Akt: protein kinase B, Wnt: wingless-type MMTV integration site, TNF: tumor necrosis factor.