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The genes or signaling pathways that positively or negatively regulate NF-κB activation in chondrocytes. In normal chondrocytes, several factors contribute to cartilage homeostasis by maintaining NF-κB activity at a basal level (left). In response to OA stimuli, the factors indicated stimulate NF-κB activation, leading to the induction of matrix-degrading enzymes and inflammatory or destructive mediators, eventually causing cartilage destruction (right).
