Table 1.

The microRNAs involved in nuclear factor-kappaB (NF-κB) signaling in Osteoarthritis (OA) chondrocytes.

miRNA(s)	Regulation by NF-κB	Target Gene(s)	Function(s) in Chondrocytes	Reference
miR-365	Increased	HDAC4	Promotes catabolism	[191]
miR-204	Increased	Multiple genes in PG biosynthesis pathway	Promotes OA development	[190]
miR-27b,-140	Increased	MMP13	Inhibits catabolism	[186,187]
miR-320	Decreased	MMP13	Inhibits catabolism	[194]
miR-92a-3p	Decreased	ADAMTS4/5	Inhibits catabolism	[193]
miR-9	ND	NF-κB p105/50	Directly inhibits NF-κB	[14]
miR-138	ND	NF-κB p65	Directly inhibits NF-κB	[196]
miR-93	ND	TLR4	Inhibits NF-κB upstream	[197]
miR-210	ND	DR6	Inhibits NF-κB upstream	[198]
miR-26a/b	ND	KPNA3	Inhibits NF-κB upstream	[199]
miR-149	ND	TAK1	Inhibits NF-κB upstream	[200]
miR-146a	Increased	TRAF6/IRAK1	Inhibits NF-κB upstream	[189,201]
		Smad4	Promotes OA development	[204,205,206]
miR-26a-5p	Decreased	iNOS	Inhibits NF-κB downstream	[192]
miR-558	Decreased	COX2	Inhibits NF-κB downstream	[195]

Abbreviations: miRNA, microRNA; PG, proteoglycan; OA, osteoarthritis; ND, not determined.