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Spatially regulated activity of RhoA and other small GTPases is necessary for coordinated PMN migration. Chemoattractants induce Rac/Cdc42 activation at the migration front (pseudopod), and RhoA activty at the cells´ rear end (uropod). Spatial regulation of small GTPase activity is mediated by localized activity of GEF (e.g., LSC, GEF-H1), and GTPase-induced activation/inhibition of GAP (e.g., FilGAP), other adaptor factors, like PTEN, and PI3K signaling.
