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Dynamic regulation of spatial activity of small GTPases confers DC migration. DC migration requires coordinated activity of Rac/Cdc42 at the front and of RhoA at the rear end as regulated mainly by GEF (e.g., ARHGEF5) and GAP (e.g., Myo9B, SWAP-70). Active RhoA and CYTIP/Cytohesin-1 are necessary to mediate inside-out activation of LFA-1 to enable binding of ICAM and, thereby, cell-cell interaction.
