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View full-text article in PMC

. 2019 Jun 29;11(7):915. doi: 10.3390/cancers11070915

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Common immune microenvironment patterns in lymphomas of B-cell origin. Left panel: cHL, PMBCL and PCNSL/PTL share the feature of genetic aberrations in the 9p24.1 locus leading to an intrinsic overexpression of PD-L1, which is associated with a good clinical response to PD-1 blockade. Middle panel: DLBCL and FL show remnants of the germinal center in their immune microenvironment and share the potential to clinically respond to CD47 blockade. Right panel: CLL has a distinct immune microenvironment which is markedly protective. BCR-inhibiting drugs release CLL cells from this niche. SIRPα = Signal regulatory protein α.