Table 1.
Key pathological features of lymphomas of B-cell origin.
| Diagnosis | Immuno-Phenotype | Characteristic Chromosomal Aberrations | Typical Neoplastic Changes | Immune TME Composition |
|---|---|---|---|---|
| DLBCL | CD20+CD5− CD23− | - | - | NK cells DCs macrophages T cells |
| CLL | CD20+CD5+ CD23+ | del(11q) del(13q), del(17p), trisomy 12 | - | Macrophages T cells |
| FL | CD20+CD10+ BCL2+BCL6+ | t(14;18)(q32;p21) | BCL2 overexpression | FDCs T cells (TFH) macrophages normal B cells |
| cHL | CD30+CD15+ | T cells macrophages eosinophils mast cells neutrophils normal B cells |
||
| MALT | CD20+CD5− CD10− | T cells FDCs macrophages normal B cells |
||
| MCL | CD20+CD5+ CD10−CD23− CCND1+ | t(11;14)(q13;q32) | CCND1 overexpression | T cells macrophages |
| PMBCL | CD20+CD3+sIg− | - | - | T cells macrophages |
| SMZL | CD20+CD5− CD10-CD23- | T cells normal B cells FDCs macrophages |
||
| BL | CD20+CD10+ BCL2−BCL6+ | t(8;14)(q24;q32) | MYC overexpression | macrophages |
| NMZL | CD20+CD5− CD10−CD23- | - | - | FDCs macrophages T cells normal B cells |
| LPL | CD20+CD10− CD23− | - | - | T cells mast cells macrophages |
| NLPHL | CD20+CD30− CD15−BCL6+ | normal B cells FDCs macrophages T cells |
||
| THRLBCL | CD20+EMA+ BCL2+BCL6+ | - | - | T cells macrophages |
DLBCL = diffuse large B-cell lymphoma; CLL = chronic lymphocytic leukemia; FL = follicular lymphoma; cHL = classical Hodgkin lymphoma; MALT = extranodal marginal zone lymphoma of mucosa associated lymphoid tissue; MCL = mantle cell lymphoma; PMBCL = primary mediastinal large B-cell lymphoma; SMZL = splenic marginal zone lymphoma; BL = Burkitt lymphoma; NMZL = nodal marginal zone lymphoma; LPL = lymphoplasmacytic lymphoma; NLPHL = nodular lymphocyte predominant Hodgkin lymphoma; THRLBCL = T-cell/histiocyte rich large B-cell lymphoma; sIg = surface Immunoglobulin; NK = natural killer; DC = dendritic cell; TFH = follicular helper T cells; FDC = follicular dendritic cell.