Table 3.
Univariate analysis of PFS and OS in relation to ANGPT2 and NOS3 polymorphisms.
| Gene Polymorphisms | Genetic Model | PFS | OS | ||||
|---|---|---|---|---|---|---|---|
| Median PFS [95% CI] | HR [95% CI] | p | Median OS [95% CI] | HR [95% CI] | p | ||
| ANGPT2 | |||||||
| rs3739392 | DOM | ||||||
| TT | 5.62 [5.03–6.73] | 1 | 14.39 [11.24–16.43] | 1 | |||
| CC/TC | 6.14 [3.91–8.54] | 0.94 [0.64–1.39] | 0.765 | 13.57 [8.15–18.00] | 0.92 [0.60–1.39] | 0.679 | |
| rs3739391 | DOM | ||||||
| CC | 5.75 [5.06–6.90] | 1 | 15.11 [12.65–18.50] | 1 | |||
| TT/CT | 6.04 [3.91–6.80] | 1.13 [0.79–1.63] | 0.506 | 11.14 [8.54–15.64] | 1.17 [0.79–1.73] | 0.445 | |
| rs3739390 | DOM | ||||||
| GG | 5.75 [5.03–6.60] | 1 | 14.36 [11.24–15.74] | 1 | |||
| CC/GC | 6.27 [2.60–12.61] | 0.83 [0.52–1.31] | 0.416 | 12.81 [8.15–20.89] | 0.88 [0.54–1.44] | 0.621 | |
| rs55633437 | DOM | ||||||
| GG | 6.27 [5.75–7.23] | 1 | 15.51 [13.57–18.40] | 1 | |||
| TT/GT | 1.58 [0.76–3.32] | 4.79 [2.73–8.35] | <0.001 | 4.66 [2.69–8.57] | 4.86 [2.73–8.67] | <0.001 | |
| rs3020221 | REC | ||||||
| GG/GA | 5.78 [5.06–6.60] | 1 | 12.81 [10.35–15.24] | 1 | |||
| AA | 8.77 [4.01–10.78] | 0.72 [0.45–1.14] | 0.163 | 18.99 [13.57–36.47] | 0.53 [0.31–0.92] | 0.024 | |
| rs1961222 | DOM | ||||||
| GG | 5.32 [3.19–6.60] | 1 | 11.24 [8.54–15.01] | 1 | |||
| AA /GA | 6.04 [5.09–8.02] | 0.93 [0.65–1.34] | 0.712 | 16.43 [13.57–18.99] | 0.67 [0.46–0.99] | 0.044 | |
| rs17063434 | DOM | ||||||
| TT | 5.62 [5.03–6.14] | 1 | 0.84 [11.99–17.77] | 1 | |||
| CC /TC | 6.80 [6.14–8.54] | 0.93 [0.55–1.56] | 0.779 | 11.24 [8.15–15.64] | 1.59 [0.94–2.69] | 0.084 | |
| rs2916747 | |||||||
| TT | 5.78 [5.06–6.60] | 1 | 14.39 [11.99–16.43] | 1 | |||
| TC | 6.27 [1.97–13.83] | 0.61 [0.34–1.10] | 0.102 | 11.70 [4.20–27.79] | 1.09 [0.61–1.94] | 0.784 | |
| NOS3 | |||||||
| NOS3 +894 (rs1799983) | DOM | ||||||
| GG | 5.22 [2.83–6.11] | 1 | 15.74 [9.23–18.50] | 1 | |||
| GT/TT | 6.60 [5.32–8.18] | 0.81 [0.57–1.16] | 0.251 | 14.29 [11.14–15.51] | 1.14 [0.77–1.68] | 0.527 | |
| VNTR4a4b | DOM | ||||||
| 4bb | 5.06 [3.75–6.11] | 1 | 11.99 [9.10–14.85] | 1 | |||
| 4aa/4ab | 7.65 [6.08–12.61] | 0.54 [0.36–0.80] | 0.002 | 17.15 [14.59–20.89] | 0.68 [0.44–1.05] | 0.080 | |
| NOS3-786 (rs2070744) | DOM | ||||||
| TT | 3.25 [2.33–5.06] | 1 | 9.10 [6.80–14.29] | 1 | |||
| CC/TC | 7.03 [6.08–8.67] | 0.43 [0.30–0.63] | <0.001 | 15.60 [13.86–19.51] | 0.65 [0.44–0.97] | 0.036 | |
Abbreviations: DOM, dominant; REC; recessive; VNTR, variable number of tandem repeats; PFS, progression-free survival; OS, overall survival; HR, hazard ratio.