Table 4.

Multivariate analysis of OS.

Patient Characteristics	HR [95% CI]	p
Extra-hepatic spread
Yes	1
No	0.54 [0.35–0.84]	0.007
Etiology
Viral—HCV	1
Biliary cirrhosis/cryptogenic	0.33 [0.08–1.39]	0.131
Alcoholic	1.69 [0.75–3.84	0.207
Metabolic syndrome	1.50 [0.80–2.83]	0.209
Viral—HBV	2.42 [1.38–4.26]	0.002
NOS3-786 (rs2070744)
TT	1
CC/TC	0.67 [0.47–0.96]	0.030
ANGPT2 rs55633437
GG	1
TT/GT	5.48 [2.85–10.54]	<0.001