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. 2019 Jul 11;20(14):3409. doi: 10.3390/ijms20143409

Figure 5.

Figure 5

AUR improves MPTP-induced movement disorders. (A) Experimental timeline of AUR injection into the MPTP-induced mouse model of PD and behavioral tests. Mice were intraperitoneally injected with MPTP (20 mg/kg) 24 h after AUR (25 mg/kg) administration; AUR was further injected 24 h and 48 h after MPTP injection. Open-field and vertical-grid tests were performed after 7 days of MPTP injection. (B) Tracks visualizing mouse movements for 1 h are presented. Eight-week-old MPTP-induced PD mice showed a decrease in movement compared with control mice, whereas AUR-cotreated mice showed improveed movement (n = 5/group). (C) Total distance moved in 1 h was determined using EthoVision software and is presented as means ± SD. (D–G) Mice were placed at the bottom of the vertical grid and allowed to climb upward while movement was recorded. Time to turn (D), total climbing time (E), time to climb down (F), and percentage of total steps missed (G) were calculated. Values are presented as means ± SD (n = 5/group; * P < 0.05, ** P < 0.01 vs. corresponding controls; ns, not significant). CN, control.