Table 3.
Development of cellulitis admission by body mass index category in metabolically healthy and unhealthy phenotypes.
| BMI Category (kg/m2) | Person-Years | Incident Cases | Incidence Rate (cases per 100,000 person-years) | Age- and Sex-Adjusted HR (95% CI) | Multivariable-Adjusted HR 1 (95% CI) | |
|---|---|---|---|---|---|---|
| Model 1 | Model 2 | |||||
| Total (n = 171,322) | ||||||
| <18.5 | 38,246.8 | 3 | 7.8 | 0.54 (0.17–1.73) | 0.55 (0.17–1.75) | 0.57 (0.18–1.83) |
| 18.5–22.9 | 303,902.3 | 54 | 17.8 | 1.00 (reference) | 1 (reference) | 1 (reference) |
| 23–24.9 | 151,692.7 | 53 | 34.9 | 1.59 (1.07–2.35) | 1.55 (1.05–2.3) | 1.48 (0.99–2.21) |
| 25–29.9 | 158,308.2 | 94 | 59.4 | 2.58 (1.8–3.68) | 2.47 (1.73–3.53) | 2.21 (1.5–3.26) |
| ≥30 | 18,305.5 | 21 | 114.7 | 5.22 (3.11–8.73) | 4.80 (2.86–8.05) | 3.78 (2.1–6.81) |
| p for trend | <0.001 | <0.001 | <0.001 | |||
| Metabolically healthy phenotype (n = 93,520) | ||||||
| <18.5 | 32,421.6 | 3 | 9.3 | 0.83 (0.25–2.77) | 0.82 (0.25–2.74) | 0.78 (0.23–2.6) |
| 18.5–22.9 | 208,329.0 | 27 | 13 | 1 (reference) | 1 (reference) | 1 (reference) |
| 23–24.9 | 68,842.8 | 22 | 32 | 2.01 (1.12–3.61) | 2.01 (1.12–3.61) | 2.16 (1.19–3.93) |
| 25–29.9 | 45,368.5 | 33 | 72.7 | 4.38 (2.54–7.54) | 4.31 (2.51–7.42) | 4.96 (2.74–8.99) |
| ≥30 | 2233.1 | 0 | – | – | – | – |
| p for trend | <0.001 | <0.001 | <0.001 | |||
| Metabolically unhealthy phenotype (n = 77,802) | ||||||
| <18.5 | 5825.2 | 0 | – | – | – | – |
| 18.5–22.9 | 95,573.3 | 27 | 28.3 | 1 (reference) | 1 (reference) | 1 (reference) |
| 23–24.9 | 82,849.9 | 31 | 37.4 | 1.15 (0.68–1.94) | 1.12 (0.66–1.9) | 1.04 (0.61–1.77) |
| 25–29.9 | 112,939.7 | 61 | 54 | 1.61 (1.01–2.58) | 1.55 (0.97–2.48) | 1.31 (0.8–2.14) |
| ≥30 | 16,072.4 | 21 | 130.7 | 4.12 (2.31–7.36) | 3.86 (2.15–6.92) | 2.77 (1.45–5.29) |
| p for trend | <0.001 | <0.001 | 0.006 | |||
p = 0.073 for the overall interaction between metabolic health status and BMI category for incident cellulitis-related admission (adjusted model 11). 1 Estimated from Cox proportional hazard models. Multivariable model 1 was adjusted for age, sex, center, year of screening exam, smoking status, alcohol intake, physical activity, total energy intake, educational level, and Charlson comorbidity index; model 2: model 1 plus adjustment for total cholesterol, HDL, triglycerides, glucose, hsCRP (high-sensitivity C-reactive protein), systolic blood pressure, and HOMA-IR (homeostasis model assessment of insulin resistance). CI = confidence interval, and HR = hazard ratio.