Table 2.

Clinical manifestations of anorexia nervosa.

Cardiovascular	Bradycardia and hypotension due to alterations in the autonomic nervous system. Electrocardiographic alterations: Atrial, ventricular arrhythmias and alterations in the QTc space. Myocardial alterations: decrease in cardiac mass, prolapse of the mitral valve and pericardial effusion.
Gastrointestinal	Delayed gastric emptying and constipation. Alterations of liver function tests. Parotid hypertrophy, loss of tooth enamel, gastroesophageal reflux, esophagitis, and oesophageal complications, Mallory–Weiss syndrome (especially in patients with purging habits, due to the chronicity of vomiting).
Neurological	Cortical atrophy and ventricular dilatation alterations. Alterations in psychological and cognitive tests.
Renal and Hydro electrolytic	Decrease in glomerular filtration rate. Hypokalaemia and hypochloremic metabolic alkalosis (vomit-induced) Metabolic acidosis (laxative abuse). Hyponatremia (diuretics abuse, potomania). Hypophosphatemia, hypokalaemia, and hypomagnesemia (refeeding syndrome, RS).
Bone	Osteopenia. Osteoporosis. Osteomalacia.
Endocrinological	Hypogonadotropic hypogonadism. Hypometabolism (resting energy expenditure, REE). Hypercortisolism, without the stigmas of Cushing’s syndrome. Euthyroid sick syndrome (low-normal range of T4 and TSH, with low levels of T3 and an increase in rT3). Hypoglycaemia.Growth and developmental delay in children.
Haematological	Bone marrow hypoplasia with gelatinous transformation presenting variable degrees of anaemia, leukopenia, and thrombocytopenia.
Dermatological	Russell’s sign. Xerosis. Lanugo. Hypercarotenaemia.