Table 2.
One-year cumulative major adverse cardiovascular events (MACE) incidence according to univariate analyses.
| Predictors | Levels | N MACE/N Total | One-Year Cumulative Incidence of MACE (95% CI) | p-Value * |
|---|---|---|---|---|
| Age | 26–54 y | 17/450 | 3.8 (2.0–5.6) | <0.0001 |
| 55–64 y | 22/443 | 5.0 (3.0–7.0) | ||
| 65–74 y | 32/418 | 7.7 (5.1–10.3) | ||
| ≥75 y | 73/402 | 18.4 (14.5–22.1) | ||
| BMI, kg/m2 | 20–24.9 | 49/554 | 9.0 (6.5–11.3) | 0.1569 |
| 25–29.9 | 50/767 | 6.6 (4.8–8.4) | ||
| 30–34.9 | 26/283 | 9.3 (5.8–12.6) | ||
| ≥35 | 10/86 | 12.0 (4.7–18.8) | ||
| GRACE score | ≤99 | 9/318 | 2.9 (1.0–4.7) | <0.0001 |
| 100–119 | 25/453 | 5.6 (3.4–7.7) | ||
| 120–139 | 29/456 | 6.4 (4.1–8.7) | ||
| 140–159 | 37/303 | 12.3 (8.5–16.0) | ||
| ≥160 | 44/183 | 24.3 (17.8–30.3) | ||
| Gender | female | 35/363 | 9.8 (6.6–12.8) | 0.3095 |
| male | 109/1350 | 8.2 (6.7–9.6) | ||
| Diabetes history | no | 97/1403 | 7.0 (5.6–8.3) | <0.0001 |
| yes | 47/310 | 15.5 (11.3–19.4) | ||
| MI history | No | 113/1467 | 7.8 (6.4–9.2) | 0.0124 |
| yes | 31/246 | 12.9 (8.5–17.0) | ||
| Hypertension history | no | 44/720 | 6.2 (4.4–7.9) | 0.0041 |
| yes | 100/993 | 10.2 (8.3–12.1) | ||
| Dyslipidemia history | no | 61/680 | 9.1 (6.9–7.9) | 0.4057 |
| yes | 82/1031 | 8.0 (6.4–12.1) | ||
| Valvular history | no | 134/1680 | 8.1 (6.8–9.4) | <0.0001 |
| yes | 10/33 | 30.3 (12.7–44.3) | ||
| Current smoker | no | 96/990 | 9.6 (7.7–11.4) | 0.0251 |
| yes | 44/690 | 6.5 (4.6–8.3) | ||
| Hs-CRP, mg/L | 0–0.99 | 12/299 | 4.1 (1.8–6.3) | <0.0001 |
| 1–1.99 | 18/280 | 6.5 (3.5–9.3) | ||
| 2–9.99 | 55/614 | 9.1 (6.8–11.4) | ||
| ≥10 | 48/317 | 15.4 (11.3–19.4) | ||
| Hs-cTnT, ng/L | 0–0.14 | 40/647 | 6.3 (4.4–8.1) | 0.0001 |
| 0.15–0.52 | 29/379 | 7.8 (5.0–10.5) | ||
| >0.52 | 65/493 | 13.3 (10.3–16.3) | ||
| TMAO, µmol/L | <2 | 25/340 | 7.4 (4.6–10.2) | 0.0001 |
| 2–2.99 | 12/350 | 3.5 (1.5–5.4) | ||
| 3–3.99 | 13/206 | 6.4 (3.0–9.7) | ||
| 4–6.99 | 27/257 | 10.6 (6.7–14.3) | ||
| ≥7 | 29/200 | 14.7 (9.6–19.4) |
* Log-rank test. Abbreviations: BMI—body mass index; GRACE—Global Registry of Acute Coronary Events; MI—myocardial infarction; Hs-CRP—high sensitivity C-reactive protein; Hs-cTnT—high-sensitivity troponin T; TMAO—trimethyl-amine-N-oxide.