Table 4.
Autoantibodies against apolipoprotein A-I (Anti-apoA-I IgGs) and major adverse cardiovascular events (MACE) (myocardial infarction, stroke, or cardiovascular (CV) death) risk according to Cox-regression analyses.
| Predictors | Unadjusted HR (95% CI) | p-Value | Adjusted HR (95% CI) ** | p-Value |
|---|---|---|---|---|
| Anti-ApoA-I IgGs OD | ||||
| ≤0.45, Q1 | Reference group | 0.0338 * | Reference group | 0.0496 * |
| 0.46–0.65, Q2 | 0.85 (0.50–1.46) | 0.5625 | 0.82 (0.48–1.40) | 0.4682 |
| 0.66–0.95, Q3 | 1.64 (1.04–2.57) | 0.0322 | 1.56 (0.99–2.44) | 0.0558 |
| >0.95, Q4 | 1.30 (0.82–2.08) | 0.2657 | 1.23 (0.77–1.97) | 0.3808 |
| GRACE score 2.0 | ||||
| ≤99 | Reference group | <0.0001 * | Reference group | <0.0001 * |
| 100–119 | 1.96 (0.92–4.20) | 0.0931 | 1.99 (0.93–4.26) | 0.0772 |
| 120–139 | 2.27 (1.07–4.79) | 0.0321 | 2.25 (1.07–4.76) | 0.0332 |
| 140–159 | 4.44 (2.14–9.19) | <0.0001 | 4.44 (2.14–9.20) | <0.0001 |
| ≥160 | 9.44 (4.61–19.35) | <0.0001 | 9.36 (4.57–19.18) | <0.0001 |
* p-Value for the overall association between the factor (all levels) and risk of MACE; ** Adjusted for the GRACE score 2.0. Abbreviations: HR—hazard ratio; OD—optical density; GRACE—Global Registry of Acute Coronary Events.