Table 6.
Exploring the factors associated with autoantibodies against apolipoprotein A-I (anti-apoA-I IgG) levels.
| Anti-apoA-I IgG Levels | ||||||
|---|---|---|---|---|---|---|
| All Patients | ≤0.45 Q1 | >0.45 and ≤0.65 Q2 | >0.65 and ≤0.95 Q3 | >0.95 Q4 | P * | |
| SBP, mmHg | ||||||
| Median (IQR) | 129 (114–145) | 129 (115–145) | 129 (115–144) | 128 (112–145) | 130 (114–146) | 0.9714 |
| Missing data | 0 | 0 | 0 | 0 | 0 | |
| DBP, mmHg | ||||||
| Median (IQR) | 75 (65–84) | 75 (66–84) | 75 (65–84) | 73 (65–84) | 74 (63–84) | 0.6476 |
| Missing data | 17 | 7 | 2 | 4 | 4 | |
| Hemoglobin, g/L | ||||||
| Median (IQR) | 138 (127–149) | 137 (124–149) | 138 (126–148) | 139 (129–148) | 139 (128–150) | 0.3715 |
| Missing data | 87 | 30 | 19 | 19 | 19 | |
| Hematocrit, % | ||||||
| Median (IQR) | 41 (38–43.3) | 41 (37–43) | 40 (37–43) | 41 (38–44) | 41 (38–44) | 0.2161 |
| Missing data | 76 | 26 | 14 | 18 | 18 | |
| Leucocytes, G/L | ||||||
| Median (IQR) | 9.6 (7.4–12.1) | 9.5 (7.3–12.0) | 9.2 (7.1–12.0) | 9.8 (7.9–12.1) | 9.8 (7.6–12.3) | 0.0340 |
| Missing data | 73 | 25 | 14 | 17 | 17 | |
| Erythrocytes, T/L | ||||||
| Median (IQR) | 4.5 (4.1–4.8) | 4.5 (4.1–4.9) | 4.4 (4.1–4.8) | 4.5 (4.2–4.8) | 4.5 (4.1–4.8) | 0.3240 |
| Missing data | 84 | 28 | 17 | 19 | 20 | |
| Lymphocytes, % | ||||||
| Median (IQR) | 1.62 (1.16–2.35) | 1.67 (1.20–2.55) | 1.54 (1.09–2.31) | 1.69 (1.19–2.34) | 1.58 (1.11–2.22) | 0.0526 |
| Missing data | 395 | 118 | 95 | 87 | 95 | |
| Neutrophils, G/L | ||||||
| Median (IQR) | 7.3 (5.3 to 10.0) | 7.0 (5.0 to 9.7) | 7.2 (4.7 to 10.1) | 7.4 (5.5 to 9.9) | 7.6 (5.5 to 10.1) | 0.1500 |
| Missing data | 412 | 122 | 97 | 93 | 100 | |
| Monocytes, % | ||||||
| Median (IQR) | 0.62 (0.45 to 0.95) | 0.63 (0.45 to 1.05) | 0.56 (0.41 to 0.92) | 0.64 (0.48 to 0.99) | 0.61 (0.45 to 0.90) | 0.1220 |
| Missing data | 398 | 118 | 96 | 88 | 96 | |
| Basophils, % | ||||||
| Median (IQR) | 0.03 (0.01–0.07) | 0.03 (0.02–0.08) | 0.03 (0.01–0.07) | 0.03 (0.01–0.07) | 0.03 (0.01–0.06) | 0.7491 |
| Missing data | 399 | 118 | 95 | 88 | 98 | |
| Eosinophils, % | ||||||
| Median (IQR) | 0.08 (0.02–0.19) | 0.10 (0.03–0.21) | 0.08 80.03–0.20) | 0.07 (0.02–0.17) | 0.07 (0.02–0.16) | 0.0237 |
| Missing data | 401 | 119 | 96 | 88 | 98 | |
| Thromboctyes, G/L | ||||||
| Median (IQR) | 215 (183–257) | 226 (188–272) | 211 (179–250) | 218 (185–253) | 208 (176–255) | 0.0026 |
| Missing data | 85 | 27 | 15 | 21 | 22 | |
| Total cholesterol, mmol/L | ||||||
| Median (IQR) | 4.9 (4.1–5.7) | 4.9 (4.1–5.8) | 4.9 (4.0–5.8) | 4.9 (4.1–5.7) | 4.7 (4.0–5.6) | 0.1602 |
| Missing data | 49 | 13 | 13 | 11 | 12 | |
| HDL, mmol/L | ||||||
| Median (IQR) | 1.13 (0.69–1.60) | 1.14 (0.93–1.40) | 1.14 (0.96–1.40) | 1.13 (0.94–1.40) | 1.10 (0.93–1.33) | 0.2852 |
| Missing data | 65 | 20 | 15 | 14 | 16 | |
| LDL, mmol/L | ||||||
| Median (IQR) | 308 (2.34–3.84) | 3.07 (2.32–3.94) | 3.13 (2.40–3.82) | 3.08 (2.37–3.81) | 2.99 (2.26–3.81) | 0.7418 |
| Missing data | 68 | 20 | 16 | 16 | 16 | |
| Triglyceride | ||||||
| Median (IQR) | 1.02 (0.69–1.60) | 1.08 (0.72–1.70) | 1.05 (0.69–1.68) | 1.00 (0.66–1.51) | 0.99 (0.69–1.48) | 0.2165 |
| Missing data | 58 | 17 | 15 | 13 | 13 | |
| Creatinine, µmol/L | ||||||
| Median (IQR) | 76 (65–91) | 75 (64–88) | 76 (66–91) | 76 (65–92) | 77 (66–92) | 0.3484 |
| Missing data | 0 | 0 | 0 | 0 | 0 | |
| NT-ProBNP, ng/L | ||||||
| Median (IQR) | 414 (131–1436) | 386 (118–1462) | 355 (129–1196) | 433 (132–1627) | 544 (159–1633) | 0.0390 |
| Missing data | 195 | 60 | 41 | 42 | 52 | |
| eGFR, mL/min | ||||||
| Median (IQR) | 90.9 (73.5–108.8) | 92.1 (75.8–110.9) | 91.0 (73.5–107.2) | 89.8 (73.5–108.3) | 90.7 (70.5–108.6) | 0.4791 |
| Missing data | 5 | 1 | 1 | 2 | 1 | |
| Renal failure (eGFR <60), n (%) | 214/1708 | 47/441 | 53/395 | 56/423 | 58/449 | 0.5828 |
* Kruskal-Wallis or Chi-2 tests (Fisher exact test for liver history). Abbreviations: Anti-apoA-I IgG—autoantibodies against apolipoprotein A-I; SBP—systolic blood pressure; DBP—diastolic blood pressure; IQR—interquartile range; HDL—high-density lipoprotein; LDL—low-density lipoprotein; NT-ProBNP—N-terminal pro-brain natriuretic peptide; eGFR—estimated glomerular filtration rate.